Two molecules, GHK and securinine topped the list and were selected out of 1,309 bioactive molecules as the best agents capable to reverse expression of 54 gene sets overexpressed in malignant invasive metastatic colon cancer, which included node molecules YWHAB, MAP3K5, LMNA, APP, GNAQ, F3, NFATC2, and TGM2, involved in regulation of multiple biochemical pathways [ 27 ]
Cancer is the uncontrolled and unorderly growth of normal cells, and the capacity of losing the controlled growth of normal cells is termed contact inhibition of proliferation [43]
10.1073/pnas.0402435101 14 BrunsN.LrcherS.MakyaK.PollardaJ.RenggliK.SpulberM
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